Product details have been supplied by the Manufacturer, and are hosted by a third party.Product Details Youtheory® Collagen Advanced Formula supplies 6,000 mg of hydrolyzed collagen (types 1, 2 & 3) per daily serving. Collagen Advanced Formula (Canada NPN #80030385) Collagen is the most abundant protein in the human body and a key constituent of skin, joints, bones, blood vessels, organs and more. The word “collagen” is derived from kolla, the Greek word for glue. Collagen is literally the substance that binds us together. It forms an extensive netlike framework throughout the inner body and imparts shape and structural strength to virtually every tissue. While bountiful in youth, the collagen content of the body gradually decreases with age… leading to thinner, weaker, less resilient tissues over time. Loss of collagen is one of the most profound consequences of the aging process. Although it is possible to boost collagen through the diet, a far better (and much more convenient) approach is through dietary supplementation. Collagen supplements contain a modified form of collagen protein that has been broken down by enzymes (through a process called hydrolysis). Hydrolyzed collagen is composed of small peptides of low molecular weight that are easily digestible, absorbed and distributed in the human body.1 ,2 Numerous clinical trials have confirmed the benefits of hydrolyzed collagen peptides for human health. Vitamin C is well-known for its antioxidant properties. But it’s also critical for internal collagen synthesis. Vitamin C is used by the body to convert “proline” into “hydroxy-proline” – an amino acid that plays a key role in collagen stability; in short, hydroxyproline puts a twist in collagen’s triple helix structure. Without this singular amino acid, collagen-containing tissues will inevitably fall apart and the body will cease to manufacture new collagen proteins. The most obvious first effects of Vitamin C absence in humans come from this resulting defect in hydroxyproline, with reduced stability of the collagen molecule, causing scurvy (gingival and hair problems caused by collagen instability). • Hydrolyzed collagen may help reduce joint pain associated with osteoarthritis.3 ,4 ,5 • Hydrolyzed collagen is a source of the essential amino acid Lysine – helps in collagen formation.6 ,7 ,8 ,9 • Vitamin C helps in connective tissue formation.10 ,11 ,12 ,13 Take three tablets twice a day. Use for a minimum of five months to see beneficial joint effects. Each bottle supplies a full 65 day supply of collagen. Hydrolyzed collagen is GRAS-affirmed (generally recognized as safe) and has been used safely for up to 6 months in human studies. Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if you have liver or kidney disease or if you have been instructed to follow a low protein diet. May cause mild gastrointestinal complaints, in which case discontinue use. Store bottle in a cool, dry place. About youtheory® The youtheory® line of health and beauty supplements were specially formulated to enhance one’s own natural beauty starting on the inside. Our high quality products were made to exceed industry standards and are packaged in innovative, premium, and eco-friendly bottles. Whether you’re 25 years old, 37, 52 or 60 your age tells a story. Be proud and claim it. Age beautifully™ with youtheory®. 1 Iwai, Koji, et al. “Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates.” Journal of agricultural and food chemistry 53.16 (2005): 6531-6536.2 Oesser, Steffen, et al. “Oral administration of 14C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL).” The Journal of nutrition 129.10 (1999): 1891-1895.3 Bruyère O, et al. Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study. Complementary Therapies in Medicine 2012;20:124-130.4 Benito-Ruiz P, et el. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition 2009;60 Suppl 2:99-113.5 Clark KL, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinions 2008;24(5):1485-1496.6 derMarderosian A, et al. The Review of Natural Products. Lysine: Issue date February 2011. St Louis (MO): Facts and Comparisons, Wolters Kluwer Health; Printed in 2008 and Updated to June 2011.7 Baziwane D, He Q. Gelatin: The paramount food additive. Food Reviews International 2003;19(4):423-435.8 Garrison RH, Somer E. Nutrition Desk Reference, 3rd edition. New Canaan (CT): Keats Publishing, 1995.9 Jansen GR. Lysine in Human Nutrition. The Journal of Nutrition 1962;76:1-35.10 IOM 2006: Institute of Medicine. Otten JJ, Pitzi Hellwig J, Meyers LD, editors. Institute of Medicine. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington (DC): National Academies Press; 2006.11 Shils ME, Olson JA, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern Nutrition in Health and Disease, 10th edition. Philadelphia (PA): Lippincott Williams & Wilkins; 2006.12 Groff J, Gropper S. Advanced Nutrition and Human Metabolism, 3rd edition. Belmont (CA): Wadsworth/Thomson Learning; 2000.13 IOM 2000: Institute of Medicine. Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Washington (DC): National Academies Press; 2000.